Mental retardation in Down syndrome: a hydrogen sulfide hpothesis.
نویسنده
چکیده
Mental retardation is progressive in Down syndrome: individuals are born with normal intelligence which starts to decline linearly within the first year. This phenomenon can be observed with phenylalanine in patients with phenylketonuria, therefore it is compatible with metabolic intoxication. The toxic compound could be hydrogen sulfide. The amount of the compound is probably increased in Down syndrome by increasing active cystathionine beta synthase. This heuristic hypothesis requires further investigation.
منابع مشابه
وضعیت حقوقی افراد مبتلا به سندرم داون
The syndrome of physical and mental symptoms that present a clinical disease or disorder is hereditary. This phenomenon is due to an irregularity in the chromosome during cell division occurs in the embryonic stages. Those who have Down syndrome in their body cells have 46 chromosomes instead of 47 chromosomes. Extra chromosome in the body of a person who has Down syndrome, causes physical and ...
متن کاملEndogenous hydrogen sulfide overproduction in Down syndrome.
The cystathionine beta synthase (CBS) gene is localized on chromosome 21 (21q22.3). This enzyme is one of three enzymes able to produce hydrogen sulfide. CBS is overexpressed in Down syndrome with levels 166% of normal values in fibroblasts [Chadefaux et al., 1985] and 1,200% in myeloblasts [Taub et al., 1999]. The CBS overexpression could induceanoverproduction ofhydrogen sulfide in Down syndr...
متن کاملاعمال حقوقی افراد مبتلا به سندرم داون
Syndrome means a set of physical and mental symptoms which is manifestation of a disease or hereditary anomaly and its Persian equivalent is “Neshanegan”. The cause of this phenomenon is a type of disorder in chromosomal arrangement which happens in the embryonic stages and at the time of cell division. Those who suffer Down syndrome include 47 chromosomes instead of 46 chromosomes ...
متن کاملThe effect of reality therapy on self-efficacy in mothers of children with Down syndrome
Introduction :Down syndrome is the most prevalent abnormal chromosomal disorder in human and the best known genetic cause of mental retardation which lays the foundations for physical and congenital defects and abnormalities. Abnormal behaviors of children with Down syndrome impair their mother's self-efficacy. The present study was conducted to investigate the effect of reality therapy on gene...
متن کاملHydrogen sulfide (H2S) - the third gas of interest for pharmacologists.
Nitric oxide (NO) and carbon monoxide (CO) synthesized from L-arginine by NO synthase and from heme by heme oxygenase, respectively, are the well-known neurotransmitters and are also involved in the regulation of vascular tone. Recent studies suggest that hydrogen sulfide (H(2)S) is the third gaseous mediator in mammals. H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase...
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عنوان ژورنال:
- Medical hypotheses
دوره 57 3 شماره
صفحات -
تاریخ انتشار 2001